Police issued a correction this afternoon after earlier reports had incorrectly indicated that the woman was from the Tweed Heads area. She was from Newcastle.
About 5.40pm a Holden Commodore was travelling north on the Pacific Highway when it crossed the median strip and crashed into a truck parked in a southbound lane.
The 27-year-old woman, believed to be the driver, was trapped for a short period of time before being released.
She died at the scene.
A 25-year-old man ,who was the front seat passenger in the car, was taken to Manning Base Hospital suffering an abrasion to the head.
Two girls aged one and a three were also in the car were also taken to Manning Base Hospital suffering minor cuts and abrasions.
A report will be prepared for the Coroner.
Police from the Manning-Great Lakes Local Area Command were appealing for witnesses.